A Polyphenolic Extract from Geranium Sanguineum L. Inhibits Influenza Virus Protein Expression
Identifieur interne : 001C86 ( Main/Exploration ); précédent : 001C85; suivant : 001C87A Polyphenolic Extract from Geranium Sanguineum L. Inhibits Influenza Virus Protein Expression
Auteurs : Julia Serkedjieva [Bulgarie]Source :
- Phytotherapy Research [ 0951-418X ] ; 1996-08.
English descriptors
- Teeft :
- Antiviral, Antiviral action, Antiviral activity, Bulgarian, Bulgarian academy, Calf serum, Cell cultures, Cell monolayers, Cell surface, Elisa, Equine influenza viruses, Geranium, Geranium sanguineurn, Influenza, Influenza viruses, Inhibitory effect, Manolova, Mdck, Medicinal plant geranium sanguineum, Mill hill, Monoclonal antibodies, Monolayers, Plant polyphenolic, Polyphenolic, Polyphenolic acids, Polyphenolic substances, Protein synthesis, Replication, Rostock, Sanguineum, Sanguineurn, Serkedjieva, Sofia, Uglrnl figure, Vanden berghe, Viral, Viral infection, Viral protein synthesis, Viral proteins, Virus inoculum.
Abstract
A polyphenolic complex (PC) with antiviral activity has been isolated from the Bulgarian medicinal plant Geranium sanguineum L. Its antiviral activity was studied with respect to the effect of the substance on the expression of influenza virus proteins on infected cell surface. ELISA with monoclonal antibodies to haemagglutinin, neuraminidase and nucleoprotein was used. By studying various strains of human, avian and equine influenza viruses it was shown that the inhibitory effect was strain‐related, and consistent with a selective antiviral action. The effect depended also on the dose of PC and the virus inoculum.
Url:
DOI: 10.1002/(SICI)1099-1573(199608)10:5<441::AID-PTR867>3.0.CO;2-9
Affiliations:
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Le document en format XML
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Inhibits Influenza Virus Protein Expression</title><author><name sortKey="Serkedjieva, Julia" sort="Serkedjieva, Julia" uniqKey="Serkedjieva J" first="Julia" last="Serkedjieva">Julia Serkedjieva</name><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Institute of Microbiology, Bulgarian Academy of Science, Acad. Georgy Bonchev str., bl. 26, 1113 Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Correspondence address: Institute of Microbiology, Bulgarian Academy of Science, Acad. Georgy Bonchev str., bl. 26, 1113 Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">10</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="441">441</biblScope><biblScope unit="page" to="443">443</biblScope><biblScope unit="page-count">3</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="1996-08">1996-08</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antiviral</term><term>Antiviral action</term><term>Antiviral activity</term><term>Bulgarian</term><term>Bulgarian academy</term><term>Calf serum</term><term>Cell cultures</term><term>Cell monolayers</term><term>Cell surface</term><term>Elisa</term><term>Equine influenza viruses</term><term>Geranium</term><term>Geranium sanguineurn</term><term>Influenza</term><term>Influenza viruses</term><term>Inhibitory effect</term><term>Manolova</term><term>Mdck</term><term>Medicinal plant geranium sanguineum</term><term>Mill hill</term><term>Monoclonal antibodies</term><term>Monolayers</term><term>Plant polyphenolic</term><term>Polyphenolic</term><term>Polyphenolic acids</term><term>Polyphenolic substances</term><term>Protein synthesis</term><term>Replication</term><term>Rostock</term><term>Sanguineum</term><term>Sanguineurn</term><term>Serkedjieva</term><term>Sofia</term><term>Uglrnl figure</term><term>Vanden berghe</term><term>Viral</term><term>Viral infection</term><term>Viral protein synthesis</term><term>Viral proteins</term><term>Virus inoculum</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A polyphenolic complex (PC) with antiviral activity has been isolated from the Bulgarian medicinal plant Geranium sanguineum L. Its antiviral activity was studied with respect to the effect of the substance on the expression of influenza virus proteins on infected cell surface. ELISA with monoclonal antibodies to haemagglutinin, neuraminidase and nucleoprotein was used. By studying various strains of human, avian and equine influenza viruses it was shown that the inhibitory effect was strain‐related, and consistent with a selective antiviral action. The effect depended also on the dose of PC and the virus inoculum.</div></front></TEI><affiliations><list><country><li>Bulgarie</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Serkedjieva, Julia" sort="Serkedjieva, Julia" uniqKey="Serkedjieva J" first="Julia" last="Serkedjieva">Julia Serkedjieva</name></region><name sortKey="Serkedjieva, Julia" sort="Serkedjieva, Julia" uniqKey="Serkedjieva J" first="Julia" last="Serkedjieva">Julia Serkedjieva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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